发明名称 |
COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING COMPLEX REGIONAL PAIN SYNDROME |
摘要 |
Oral dosage forms of osteoclast inhibitors, such as nitrogen-containing bisphosphonates, can be used to treat or alleviate pain or related conditions such as complex regional pain syndrome. |
申请公布号 |
US2017049791(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
US201615347696 |
申请日期 |
2016.11.09 |
申请人 |
ANTECIP BIOVENTURES II LLC |
发明人 |
Tabuteau Herriot |
分类号 |
A61K31/675;A61K9/00 |
主分类号 |
A61K31/675 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating pain associated with complex regional pain syndrome comprising orally administering a dosage form comprising zoledronic acid in an acid form or a salt form to a human being suffering from complex regional pain syndrome;
wherein the human being has an identifiable inciting trauma associated with the complex regional pain syndrome; wherein the dosage form is free of bioavailability enhancing agents to the extent that the bioavailability of zoledronic acid in the dosage form is no higher than the bioavailability of an orally administered unenhanced disodium salt of zoledronic acid; and wherein about 0.4 mg/kg to about 2.8 mg/kg of zoledronic acid is orally administered to the human being 2 to 10 times at a frequency of about once weekly to about once a month. |
地址 |
New York NY US |