TOPICAL COMPOSITION

摘要

The inventors have observed that aqueous mustard seed extract appears to be cytotoxic to fibroblast cells. The cytotoxicity of the aqueous mustard seed extract appears to abate when the extract is heat treated at 120° C. for 15 minutes. The heat treated aqueous mustard seed extract when combined with exogenous myrosinase is not cytotoxic but can induce a modest increase in HO-1 content in cultured fibroblasts and thus would be expected to be useful in a topical composition for treating/preventing itchy skin, particularly the scalp. This invention thus relates to the provision of a topical composition for treating/preventing itchy skin, particularly the scalp.

主权项

1. A topical composition comprising:
(a) ground glucosinolate-containing plant material; (b) an enzyme source comprising thioglucosidase; (c) water; and (d) a compound selected from the group consisting of humectants, organic solvents including petroleum jelly, silicones, perfume, organic/inorganic sunscreens;wherein the glucosinolate-containing plant material is heat treated at a temperature of at least 100 degrees centigrade for at least 5 minutes before grinding; andwherein the combination of (a), (b) and (c) only combine on use of the topical composition;and wherein the glucosinolate-containing plant material is selected from the group of families consisting of Bataceae, Brassicaceae, Bretschneideraceae, Capparaceae, Caricaceae, Euphorbiaceae, Gyrostemonaceae, Limnanthaceae, Moringaceae, Pentadiplandraceae, Phytolaccaceae, Pittosporaceae, Resedaceae, Salvadoraceae, Tovariaceae, Tropaeolaceae, Akaniaceae, Cleomaceae, Emblingiaceae, Koeberliniaceae, Setchellanthaceae and mixtures thereof, preferably Brassicaceae, most preferably the species Brassica juncea.