发明名称 |
METHODS OF ENHANCING STEM CELL ENGRAFTMENT |
摘要 |
An effective amount of a composition comprising a stem cell, a stem cell engraftment enhancer, and a carrier fluid, for use in the treatment of an individual having a disease or at risk of developing a disease, wherein the disease is a vascular-associated disease and/or a muscular disease. A composition comprising PGI2-overexpressing human mesenchymal stem cells (PGI2-hMSCs), and a carrier fluid; wherein an effective amount of the composition is administered via a single treatment stream as an intramuscular injection to an individual having a disease or at risk of developing a disease, wherein the disease is a vascular-associated disease and/or a muscular disease, and wherein stem cell engraftment is enhanced in said individual by greater than about 200%, when compared to stem cell engraftment in an individual treated with a composition lacking the stem cell engraftment enhancer. |
申请公布号 |
US2017049822(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
US201515305717 |
申请日期 |
2015.04.22 |
申请人 |
TEXAS HEART INSTITUTE |
发明人 |
LIU Qi;DIXON Richard A.F. |
分类号 |
A61K35/28;A61K31/5578 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
1. An effective amount of a composition comprising:
a stem cell, a stem cell engraftment enhancer, and a carrier fluid, for use in the treatment of an individual having a disease or at risk of developing a disease, wherein the disease is a vascular-associated disease and/or a muscular disease. |
地址 |
Houston TX US |