Metabolic and Genetic Biomarkers for Memory Loss

摘要

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and also analyzing the gene expression profile from leukocytes and comparing the value of the subject's biomarker profile (lipidomic profile plus gene expression profile) with the value of a normal biomarker profile. A change in the value of the subject's biomarker profile, including a change in the subject's biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

主权项

1. A method of determining if a subject has an increased risk of suffering from memory impairment, the method comprising
a) analyzing at least one sample from the subject to determine a value of the subject's biomarker profile, and b) comparing the value of the subject's biomarker profile with the value obtained from subjects determined to define a normal biomarker profile, to determine if the subject's biomarker profile is altered compared to a normal biomarker profile, wherein a change in the value of the subject's biomarker profile is indicative that the subject has an increased risk of suffering from future memory impairment compared to those defined as having a normal biomarker profile.