METHOD OF INDUCING A T-CELL RESPONSE TO PHOSPHOPEPTIDES USING NUCLEIC ACIDS ENCODING PHOSPHOPEPTIDE MIMETICS

摘要

Provided are compositions and methods useful as therapeutic vaccines (e.g., cancer vaccines), and methods of producing such compositions. The compositions disclosed herein generally employ an RNA or DNA molecule, which may be a modified nucleotide, encoding a phosphopeptide mimetic of a phosphopeptide that occurs in at least one cancer cell.