发明名称 Guanidine compound
摘要 Abstract [Abstract] [Problem] 5 The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases. [Means for Solution] The present inventors have conducted intensive studies on a compound having a 10 VAP-1 inhibitory activity, and as a result, they have found that the compound or a salt thereof of the present invention exhibits an excellent VAP-I inhibitory activity and is useful for preventing and/or treating.VAP- 1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. In addition, the present invention relates to a pharmaceutical composition, in particular, a 15 pharmaceutical composition for preventing and/or treating VAP- -related diseases, which comprises the compound or a salt thereof of the present invention, and an excipient. [Selected Figure] Nil
申请公布号 AU2016202010(B2) 申请公布日期 2017.02.23
申请号 AU20160202010 申请日期 2016.03.31
申请人 Astellas Pharma Inc. 发明人 Yoshihara, Kousei;Suzuki, Daisuke;Yamaki, Susumu;Yamada, Hiroyoshi;Mihara, Hisashi;Seki, Norio
分类号 C07D205/04;A61K31/426;A61K31/4402;A61K31/4545;A61K31/495;A61K31/496;A61K31/505;A61K31/506;A61K31/5377;A61K31/551;A61P1/02;A61P1/04;A61P1/16;A61P3/04;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P19/06;A61P21/00;A61P25/00;A61P25/04;A61P25/28;A61P27/02;A61P29/00;A61P37/00;A61P37/02;A61P37/06;A61P43/00;C07D211/26;C07D211/46;C07D211/56;C07D211/58;C07D211/62;C07D213/38;C07D213/74;C07D213/79;C07D213/80;C07D213/81;C07D217/06;C07D217/22;C07D237/20;C07D239/34;C07D239/42;C07D239/48;C07D241/04;C07D241/20;C07D243/08;C07D277/20;C07D277/42;C07D277/44;C07D277/46;C07D277/56;C07D277/62;C07D295/08;C07D295/18;C07D295/20;C07D295/22;C07D307/24;C07D309/04;C07D309/06;C07D309/08;C07D309/14;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/04;C07D405/06;C07D405/12;C07D405/14;C07D409/12;C07D413/04;C07D413/12;C07D413/14;C07D417/12;C07D471/04;C07D471/10;C07D487/04;C07D487/08;C07D487/10;C07D495/04;C07D513/04 主分类号 C07D205/04
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