| 发明名称 |
VASCULAR RE-MODELLING |
| 摘要 |
The present invention is based on the finding that microRNA from the microRNA gene cluster located on the human chromosomal at locus 14q32 play an important role in vascular development and re-modelling. Modulators of any of the 14q32 microRNA may be exploited as a means to modulate vascular re-modelling processes and/or in the treatment and/or prevention of vascular disorders or disease. |
| 申请公布号 |
US2017051279(A1) |
申请公布日期 |
2017.02.23 |
| 申请号 |
US201615099027 |
申请日期 |
2016.04.14 |
| 申请人 |
Academisch Ziekenhuis Leiden a/u Leiden University Medical Center |
发明人 |
Nossent Anne Yael;Quax Paulus Hubertus Andreas;Bastiaansen Antonius Johannes Nicolaas;Welten Sabine Marlies Janine;Wezel Anouk;Bot Ilze |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for modulating vascular re-modelling processes and/or for treating or preventing a vascular disorder, said method comprising administering to a subject in need thereof a modulator of one or more 14q32 microRNAs. |
| 地址 |
Leiden NL |
