发明名称 |
ANTI-CD134 (OX40) ANTIBODIES AND USES THEREOF |
摘要 |
The invention provides antibodies that specifically bind to human CD134. Invention anti-human CD134 antibodies specifically bind to the extracellular domain of human CD134, including non-OX40 ligand (OX40L) binding domains on human CD134, which is expressed on e.g. activated human conventional effector CD4 and/or CD8 T lymphocytes (Teffs) and on activated human suppressive regulatory CD4 lymphocytes (Tregs). Invention anti-human CD134 antibodies are useful (e.g. to empower Teffs anti-cancer effector function and/or to inhibit Tregs suppressive function) for cancer treatment. |
申请公布号 |
US2017051069(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
US201615247425 |
申请日期 |
2016.08.25 |
申请人 |
Biocerox Products B.V. ;Janssen Pharmaceuticals, Inc. |
发明人 |
Simons Petrus Johannes;Boon Louis |
分类号 |
C07K16/28;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Utrecht NL |