COMBINATION THERAPY OF ANTIBODIES AGAINST HUMAN CSF-1R AND ANTIBODIES AGAINST HUMAN PD-L1

摘要

The present invention relates to the combination therapy of specific antibodies which bind human CSF-1R with specific antibodies which bind human PD-L1.

主权项

1. A method for treating cancer, preventing or for treating metastasis, for treating inflammatory diseases, for treating bone loss, for treating or delaying progression of an immune related disease, or for stimulating an immune response or function, the method comprising administering to a patient in need thereof an effective amount of an antibody which binds to human colony stimulating factor 1 receptor (CSF-1R), and an antibody which binds to human programmed death-ligand 1 (PD-L1),
wherein the antibody which binds to human CSF-1R comprises:
a) a heavy chain variable domain VH of SEQ ID NO:23 and a light chain variable domain VL of SEQ ID NO:24, orb) a heavy chain variable domain VH of SEQ ID NO:31 and a light chain variable domain VL of SEQ ID NO:32, orc) a heavy chain variable domain VH of SEQ ID NO:39 and a light chain variable domain VL of SEQ ID NO:40, ord) a heavy chain variable domain VH of SEQ ID NO:47 and a light chain variable domain VL of SEQ ID NO:48, ore) a heavy chain variable domain VH of SEQ ID NO:55 and a light chain variable domain VL of SEQ ID NO:56.