MICROFLUIDIC PLATFORM DEVICE AND METHOD FOR IDENTIFYING NEUTRALIZING AND/OR ENHANCING ANTIBODIES THROUGH DIRECT FUNCTIONAL ASSAYS

摘要

The microfluidic platform device of the claimed invention makes use of a high throughput lab-on-a-chip format to determine the functional profile of antibodies elicited by infection or vaccination against infection for any pathogen. It can be used to evaluate vaccines, evaluate whether vaccinated individuals show indices of protection, determine whether individuals display resistance or susceptibility to infection, discover new vaccine antigens, discover and test therapeutic interventions, or evaluate mechanisms of disease.