METHOD OF DETECTING AT LEAST ONE MECHANISM OF RESISTANCE TO CEPHALOSPORINS BY MASS SPECTROMETRY

摘要

The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.

主权项

1. A method of detecting cephalosporin resistance, comprising:
performing mass spectrometry on a sample to determine whether the sample includes at least one marker of resistance to at least one cephalosporin,
wherein:the resistance marker indicates that a microorganism expresses a protein conferring resistance to at least one cephalosporin; andthe resistance marker is at least one TEM peptide having any of the full-length amino acid sequences set forth in SEQ ID NOS: 166-230, 232-257, 259-261, 1923, 1927, and 1928.