| 摘要 |
Ceftezol drug intermediates 2-(1H-1-4 imidazolyl) acetic acid synthesis method, comprising the following steps: (I) a reaction vessel was added 0.51mol 2-(5-nitro-1H-1-tetrazolyl) acetic acid (2), 0.56-0.59mol o-bromo phenol solution (3), controlling the stirring speed at 130-150rpm, 0.26mol cuprous chloride was added, 310ml potassium chloride solution, controlling the temperature of the solution at 10-15 C, reacted for 7-9h, the temperature of the solution is reduced to 5-8 C, by adding ammonium nitrate solution, the pH was adjusted to 6-7, extracted with dimethylsulfoxide 5-7 times, the combined organic layers was washed with cyclohexanol solution, dehydrated with a dehydrating agent, dimethylsulfoxide was distilled off under vacuum distillion, the residue was added to N-dimethylformamide solution, precipitated solid was filtered, recrystallized from acetamide solution, got crystals 2-(1H-1-tetrazolyl) acetic acid. |
