PROGRAMMABLE MIP CATCH AND RELEASE TECHNOLOGY

摘要

Programmable molecular imprinted polymers (MIPs) that have modified binding site kinetics for target imprintable entities (TIEs) that operate to control the adsorption, binding, release and equilibrium distribution of related materials into and out of the MIPs, which are useful for the controlled adsorption, controlled release and control of concentrations of such materials in media including gases, liquids, fluids, biological systems, solutions and other environments. When a collective plurality of the MIPs with modified binding site kinetics are combined, the resulting MIP systems can be tailored to exhibit pseudo zero- and first-order kinetics, as well as higher kinetic profiles, and when further combined with time-delay functionality, can be tailored to exhibit delayed uptake and release, ramped uptake and release of materials, step functions, polynomial, geometric, exponential and other unique kinetic profiles of material exchange between the novel MIPs and a fluid media that are not readily achievable by other means.

主权项

1. A molecularly imprinted polymer system for use in the catch and release of multiple materials comprising:
(a) a first molecularly imprinted polymer with at least one first suboptimal average associative binding constant with respect to a first material to be released; (b) a second molecularly imprinted polymer with at least one second suboptimal average associative binding constant with respect to a second material to be captured; wherein said first molecularly imprinted polymer is dosed with said first material to a desired degree of saturation. wherein said first molecularly imprinted polymer and said second molecularly imprinted polymer are introduced or contacted with a fluid media; and wherein said first and said second molecularly imprinted polymers operate to controllably release a first material into said fluid media and controllably adsorb a second material from said fluid media, respectively.