发明名称 |
Derivatives of Ergostatrien-3-Beta-OL From Antrodia Camphorata and Antiglycemic, Antihyperlipidemic and Decreasing Hepatic Fat Use Thereof |
摘要 |
The present invention provides a method for treating diabetes, hyperlipidemia or hepatic total lipids by using ergostatrien-3β-ol and its derivatives, as well as a method for decreasing blood glucose and HbA1c levels and reducing blood total cholesterol and triglyceride levels, whereas increasing blood HDL-C levels; and a method for decreasing hepatic total lipid and triacylglycerol levels; and increasing expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt in skeletal muscle tissue, and phospho-AMPK in both skeletal muscle and liver tissue using ergostatrien-3β-ol and its derivatives. |
申请公布号 |
US2017049787(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
US201615011342 |
申请日期 |
2016.01.29 |
申请人 |
SHIH Chun-Ching |
发明人 |
KUO Yueh-Hsiung;SHIH Chun-Ching;LIN Cheng-Hsiu |
分类号 |
A61K31/575;A61K36/07 |
主分类号 |
A61K31/575 |
代理机构 |
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代理人 |
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主权项 |
1. A method for treating diabetes, hyperlipidemia or hepatic total lipids, comprising administering to a subject in need thereof an effective amount of compounds represented by formula (I) wherein R is a hydrogen atom, |
地址 |
Taichung City TW |