SIRP-alpha variant constructs and uses thereof

摘要

SIRP-ALPHA VARIANT CONSTRUCTS AND USES THEREOF The invention relates to compositions and methods of SIRP-a variant constructs including SIRP-a variants. The SIRP-a variant constructs may be engineered in a variety of ways to respond to environmental factors, such as pH, hypoxia, and/or the presence of tumor-associated enzymes or tumor associated antigens. The SIRP-a variant constructs of the invention may be used to treat various diseases, such as cancer, preferably solid tumor or hematological cancer. (4 (D4 U