EXTRACELLULAR TARGETED DRUG CONJUGATES

摘要

Extracellular drug conjugates (EDCs) targeting an extracellular protein or portion thereof (e.g., CD38) and comprising a non-cleavable linker including one or two nitrogen heteroatoms are useful in the treatment of diseases such as cancer and immune disorders, including asthma.

主权项

1. An extracellular-targeted drug conjugate (EDC) comprising a targeting moiety linked by a stable or non-cleavable linker to an agent, wherein the targeting moiety binds to an extracellular protein or fragment thereof, wherein the agent binds to or modifies the activity of a Na,K-ATPase, and wherein the non-cleavable linker includes one or two nitrogen heteroatoms.