发明名称 CYCLOPROPYLDERIVATIVES AND THEIR USE AS KINASE INHIBITORS
摘要 The invention generally relates to cyclic compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable salt thereof and pharmaceutical comopositions comprising the multicyclic compounds. The invention also relates to a method for treating a disease or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, an inflammatory diseases or an immune system disease (e.g., a T-Cell mediated autoimmune disesase) in a subject in need thereof. The method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, or a composition comprising a compound of the invention, or a pharmaceutically acceptable salt thereof.
申请公布号 WO2017031204(A1) 申请公布日期 2017.02.23
申请号 WO2016US47337 申请日期 2016.08.17
申请人 KARYOPHARM THERAPEUTICS INC. 发明人 BALOGLU, Erkan;SHACHAM, Sharon;SENAPEDIS, William
分类号 C07D405/14;A61K31/443;A61K31/4439;A61P29/00;A61P35/00;A61P37/00;C07D405/12;C07D413/14 主分类号 C07D405/14
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