发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF JUVENILE NEURONAL CEROID LIPOFUSCINOSIS AND RELATED DISORDERS |
摘要 |
Provided are materials and methods for the prevention and treatment of Juvenile Neuronal Ceroid Lipofuscinosis comprising administration of an effective amount of at least one of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor. In some embodiments, the methods comprise administration of an effective amount of each of a hemi-channel inhibitor and a phosphodiesterase-4 inhibitor. Also provided are pharmaceutical compositions comprising a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor, as well as kits comprising at least one effective dose of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor or a combination of both. |
申请公布号 |
US2017049761(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
US201615251855 |
申请日期 |
2016.08.30 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA |
发明人 |
Kielian Tammy |
分类号 |
A61K31/4425;A61K38/17;A61K31/4545;A61K31/522;A61K31/4015;A61K31/44 |
主分类号 |
A61K31/4425 |
代理机构 |
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代理人 |
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主权项 |
1. A method of reducing the rate of development of Juvenile Neuronal Ceroid Lipofuscinosis comprising administering an effective amount of a hemi-channel inhibitor or a phosphodiesterase-4 inhibitor to a subject. |
地址 |
Lincoln NE US |