| 摘要 |
A liquid crystalline drug delivery system for ocular administration. The drug delivery system, which is mucoadhesive, biocompatible, non-irritating, and tissue permeable, contains nanoparticles stably dispersed in an aqueous solution and can be formulated for sustained release. Also provided are methods for producing the drug delivery system and methods for treating ocular disorders by administering it to a subject. |
| 主权项 |
1. A method for producing a liquid crystalline drug delivery system, the method comprising:
forming a first solution containing a lipidic component and an alcohol, the first solution being maintained at a temperature of 40-55° C.; obtaining a second solution that includes a mucoadhesive hydrophilic polymer and a buffer, the second solution being aqueous and maintained at a temperature of 5-55° C.; mixing the first solution and the second solution to form a combined nano/microdispersion, the mixing accomplished by a high energy mixing process selected from sonication, high shear mixing, and a combination thereof; subjecting the combined nano/micro-dispersion to microfluidization at a temperature of −10° C. to room temperature to form a nano-dispersion; and incubating the nano-dispersion at 2-5° C. to form a liquid crystalline drug delivery system,wherein a weight ratio between the first solution and the second solution is 1:1 to 1:15, the lipidic component includes phosphatidylcholine and medium chain triglycerides, the alcohol is cetyl alcohol, and the mucoadhesive hydrophilic polymer is selected from the group consisting of sodium hyaluronate, xanthan gum, guar gum, carboxymethyl cellulose, 1-4 beta glucan, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), tamarind seed polysaccharide, sodium alginate, polycarbopol, polycarbophil, and a mixture thereof. |
