发明名称 |
c-Met modulators and methods of use |
摘要 |
C:lNRPonIbimCOJAMUII7f42_l.DOC-2627/2 0 The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed 5 cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. 10 The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds. |
申请公布号 |
AU2017200555(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
AU20170200555 |
申请日期 |
2017.01.27 |
申请人 |
Exelixis, Inc. |
发明人 |
Bannen, Lynne Canne;Chan, Diva Sze-Ming;Chen, Jeff;Dalrymple, Lisa Esther;Forsyth, Timothy Patrick;Huynh, Tai Phat;Jammalamadaka, Vasu;Khoury, Richard George;Leahy, James William;Mann, Grace;Mann, Larry W.;Nuss, John M.;Parks, Jason Jevious;Takeuchi, Craig Stacy;Wang, Yong;Xu, Wei;Mac, Morrison B. |
分类号 |
C07D215/16;A61K31/47;A61K31/535;C07D215/20;C07D413/00 |
主分类号 |
C07D215/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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