| 发明名称 |
MONOVALENT BLOOD BRAIN BARRIER SHUTTLE MODULES |
| 摘要 |
Herein is reported a blood brain barrier shuttle module comprising a brain effector entity, a linker and one monovalent binding entity which binds to a blood brain barrier receptor, wherein the linker couples the effector entity to the monovalent binding entity which binds to the blood brain barrier receptor wherein the monovalent binding entity does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03). |
| 申请公布号 |
US2017051071(A1) |
申请公布日期 |
2017.02.23 |
| 申请号 |
US201615203057 |
申请日期 |
2016.07.06 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
RUEGER Petra;TIEFENTHALER Georg;MOESSNER Ekkehard;NIEWOEHNER Jens;HUGENMATTER Adrian;SHAO Cuiying;ROS Francesca;XU Gang |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A blood brain barrier shuttle module comprising a brain effector entity, optionally a linker and exactly one (monovalent) binding entity which binds to a blood brain barrier receptor, wherein the linker if present couples the effector entity to the monovalent binding entity, which binds to the blood brain barrier receptor, wherein the (monovalent) binding entity, which binds to a blood brain barrier receptor, does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03). |
| 地址 |
Little Falls NJ US |
