发明名称 COMPOSITION FOR INDUCING DIFFERENTIATION
摘要 To provide a differentiation-inducing composition and a method for producing the differentiation-inducing composition, the present disclosure describes use of a degradation product containing at least a portion of the triple helical domain of collagen or atelocollagen.
申请公布号 US2017051043(A1) 申请公布日期 2017.02.23
申请号 US201515307441 申请日期 2015.04.30
申请人 Kinki University 发明人 Morimoto Koichi;Kunii Saori;Yamamoto Ei;Ito Hiroyuki;Kuboki Yoshinori
分类号 C07K14/78 主分类号 C07K14/78
代理机构 代理人
主权项 1. A differentiation-inducing composition for inducing cell differentiation, the differentiation-inducing composition comprising: a degradation product of a collagen or an atelocollagen, the degradation product containing at least a portion of a triple helical domain of the collagen or the atelocollagen, the degradation product resulting from cleavage of a chemical bond between X1 and X2, between X2 and G, or between X4 and G in an amino acid sequence in (1) below within the triple helical domain, cleavage of a chemical bond between X1 and X2, between X2 and G, between X4 and G, between G and X7, or between X14 and G in an amino acid sequence in (2) below within the triple helical domain, or cleavage of a chemical bond between Y1 and Y2 in an amino acid sequence in (3) below at an amino terminus of the triple helical domain, the amino acid sequence in (1) or (2) being at an amino terminus of the triple helical domain, (1) -G-X1-X2-G-X3-X4-G-X5-X6-G-, (2) -G-X1-X2-G-X3-X4-G-X5-X6-G-X7-X8-G-X9-X10-G-X11-X12-G-X13-X14-G-, (3) -Y1-Y2-Y3-G-Y4-Y5-G-Y6-Y7-G-Y8-Y9-G-, where G represents glycine, and X1 to X14 and Y1 to Y9 each represent an amino acid.
地址 Osaka JP