| 摘要 |
A therapeutic dosage form includes a pharmaceutically active ingredient, a crosslinked polyacid, and a linear polyacids. The crosslinked polyacid is insoluble in water, and the linear polyacid is soluble in water. The linear polyacid possesses sufficient binding sites to form a stable complex with the pharmaceutically active ingredient. The ingredients are formed into a tablet or capsule, either admixed, in layers, or separated by a coating. Abuse is deterred in that crushing causes the active ingredient to be bound and not abusable, and placing the dosage in solution causes a strong complex to be formed between the polyacid and the active ingredient, including a solution with ethanol. Other therapeutic dosage forms for reducing the incidence of tampering and abuse of pharmaceutical products and alcohol, and specifically preventing the isolation and concentration of drug constituents for misuse, and preventing excessive intake are also disclosed. |
