发明名称 |
THERAPEUTIC AGENT COMPRISING HUMANIZED ANTI-EPIREGULIN ANTIBODY AS ACTIVE INGREDIENT FOR NON-SMALL-CELL LUNG CARCINOMA EXCLUDING ADENOCARCINOMA |
摘要 |
The present inventors successfully produced therapeutic agents for non-small cell lung cancer except adenocarcinoma, comprising as active ingredient an anti-Epiregulin antibody that shows cross-species reactivity between the human animal and cynomolgus which is a non-human animal, an anti-Epiregulin antibody with suppressed chemical degradation, an anti-Epiregulin antibody with reduced isoelectric point, an anti-Epiregulin antibody with increased midpoint temperature of thermal denaturation, or an anti-Epiregulin antibody with reduced amount of aggregates, generated by appropriately substituting amino acid residues in the variable-region sequences of a humanized EP27 antibody that inhibits cancer cell proliferation by exerting a cytotoxicity and a neutralizing activity against human Epiregulin-expressing cancer cells. |
申请公布号 |
EP3015115(A4) |
申请公布日期 |
2017.02.22 |
申请号 |
EP20140818552 |
申请日期 |
2014.06.23 |
申请人 |
Chugai Seiyaku Kabushiki Kaisha;Miyagi Cancer Center Research Institute |
发明人 |
SUZUKI, Masami;KATO, Atsuhiko;TAKEIRI, Etsuko;HASHIMOTO, Eri;OUCHI, Kaori;SATOH, Kennichi |
分类号 |
A61K39/395;A61P35/00;A61P43/00;C07K16/30;C07K16/46;C12N15/09;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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