AAV VECTORS FOR VASCULAR GENE THERAPY IN CORONARY HEART DISEASE AND PERIPHERAL ISCHAEMIA

摘要

The invention concerns the development of gene therapy for coronary heart disease and peripheral ischaemia in mammals. One embodiment is an adeno-associated virus vector (AAV vector) comprising a first gene that codes for a myocardin-related transkriptionsfactor A (MRTF-A). The invention also concerns a pharmaceutical composition comprising an AAV vector as per the invention and a pharmaceutically acceptable carrier. Methods for producing the claimed vector are also disclosed.