摘要 |
The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens. |
申请人 |
Johnson & Johnson Vision Care Inc. |
发明人 |
GALLOIS-BERNOS, Annabelle;MOLOCK, JR., Frank, F.;DAVIS, Carrie, L.;LORENZ, Kathy, Osborn;YOUNG, James, K.;CANAVAN, Kristy, L.;LU, Fang |