发明名称 |
Nucleic acid for coding chimeric antigen receptor protein and T lymphocyte for expression of chimeric antigen receptor protein |
摘要 |
A nucleic acid for coding a chimeric antigen receptor protein expressed on the surface of a human T lymphocyte. The chimeric antigen receptor protein comprises an extracellular binding domain, a transmembrane domain and an intracellular signal domain that are orderly connected. The extracellular binding domain comprises a single-chain antibody scFv (EGFR) for specific recognition of 287th to 302th amino acid epitopes of a human epidermal growth factor receptor (EGFR). |
申请公布号 |
GB2541599(A) |
申请公布日期 |
2017.02.22 |
申请号 |
GB20160020536 |
申请日期 |
2014.05.14 |
申请人 |
Carsgen Therapeutics Limited |
发明人 |
Zonghai Li;Huiping Gao;Hua Jiang;Bizhi Shi |
分类号 |
C12N15/62;C12N5/10;C12N15/63;C12N15/867 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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