发明名称 |
C-ARYL INDICAN DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USES THEREOF |
摘要 |
This invention relates to a kind of C- aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with
via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with
via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C- aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C- aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C- aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors. |
申请公布号 |
EP3133071(A1) |
申请公布日期 |
2017.02.22 |
申请号 |
EP20150780125 |
申请日期 |
2015.04.01 |
申请人 |
Shanghai De Novo Pharmatech Co Ltd. |
发明人 |
GAO, Daxin;YANG, Heping;WANG, Pei |
分类号 |
C07D407/12;A61K31/351;A61P3/04;A61P3/06;A61P3/10;A61P9/12 |
主分类号 |
C07D407/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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