摘要 |
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography. |
申请人 |
Modernatx, Inc.;Hoge, Stephen, G.;Issa, William, Joseph;Miracco, Edward, J.;Nelson, Jennifer;Reynders, John Van Wicheren, III;Stanton, Matthew |
发明人 |
HOGE, Stephen, G.;ISSA, William, Joseph;MIRACCO, Edward, J.;NELSON, Jennifer;REYNDERS, John Van Wicheren, III;STANTON, Matthew |