| 主权项 |
1. A compound having a structure represented by formula (I): wherein:
Q1 is selected from N and CR1a;Q2 is selected from N and CR1b, or can optionally cyclize with Q3 to form a C5 or C6 saturated heterocycle;Q3 is selected from N and CR1c, or can optionally cyclize with Q2 to form a C5 or C6 saturated heterocycle;Q4 is selected from N and CR1d; and wherein 0, 1, or 2 of Q1, Q2, Q3 and Q4 are N;R1a, R1b, R1c, and R1d, when present, are each independently selected from hydrogen, halogen, hydroxyl, cyano, C1-C3 alkyl sulfone, C1-C3 polyhaloalkyl sulfone, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkoxy, (C1-C6) alkoxy-(C1-C6) alkyl, (C1-C6) alkylamino, (C1-C6) haloalkyl-oxy-(C1-C6) alkyl, (C1-C6) polyhaloalkyl-oxy-(C1-C6) alkyl, (C1-C6) polyhaloalkyl-(C1-C6) alkoxy, and (C1-C6) dialkylamino; n is 0-5;X is independently selected from optionally substituted CH2-aryl, CH2-heteroaryl, CH2-biaryl, or wherein:Q5 is selected from N, CR1a, and R1a; andn is 0-5;R2 is selected from hydrogen, C1-C3 alkyl, C1-C3 haloalkyl, and C1-C3 polyhaloalkyl, (C1-C3) polyhaloalkyl-oxy-(C1-C3) alkyl, and (C1-C3) haloalkyl-oxy-(C1-C3) alkyl, andA is optionally substituted and chosen from imidazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridinyl, pyrimidinyl, thiadiazolyl, thiazolyl, imidazothiadiazolyl, imidazooxadiazole, imidazothiazole, thiazolotriazole, and triazolyl;or a pharmaceutically acceptable salt, solvate, or polymorph thereof. |
