发明名称 |
B7-H3L cell surface antigen and antibodies that bind thereto |
摘要 |
The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10. |
申请公布号 |
US9574007(B2) |
申请公布日期 |
2017.02.21 |
申请号 |
US201414294935 |
申请日期 |
2014.06.03 |
申请人 |
MacroGenics, Inc. |
发明人 |
Mather Jennie P.;Li Ronghao;Pan Zhuangyu;Roberts Penelope E. |
分类号 |
A61K39/395;C07K16/30;C07K14/705;C07K16/28;G01N33/574;A61K45/06;A61K47/48;A61N5/10;A61K38/00;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
AuerbachSchrot LLC |
代理人 |
Schrot William C.;AuerbachSchrot LLC |
主权项 |
1. A method of treating cancer in a subject having a cancer comprising administering to the subject a composition comprising a therapeutically effective amount of an immunoglobulin polypeptide or an antigen-binding fragment thereof associated with a chemotherapeutic agent, wherein:
said immunoglobulin polypeptide or antigen-binding fragment thereof specifically binds to an epitope of a B7-H3L protein that is expressed and exposed in its native conformation on the surface of a cancer cell of said cancer, wherein said epitope is insufficiently expressed on the surface of a living normal cell to exhibit binding by said immunoglobulin polypeptide; said immunoglobulin polypeptide or antigen-binding fragment thereof can be internalized into said cancer cell expressing B7-H3L; and said immunoglobulin polypeptide or antigen-binding fragment thereof comprises the amino acid sequences of complementarity determining regions of the monoclonal antibody expressed by the hybridoma having ATCC Deposit No. PTA-4217, ATCC Deposit No. PTA-4218, ATCC Deposit No. PTA-4244, or ATCC Deposit No. PTA-4245. |
地址 |
Rockville MD US |