| 发明名称 | Chimeric inhibitor molecules of complement activation | ||
| 摘要 | The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides. | ||
| 申请公布号 | US9573984(B2) | 申请公布日期 | 2017.02.21 |
| 申请号 | US201414585369 | 申请日期 | 2014.12.30 |
| 申请人 | RIGSHOSPITALET;KOBENHAVNS UNIVERSITET;SYDDANSK UNIVERSITET | 发明人 | Garred Peter;Glue Tina Hummelshoj;Skjodt Mikkel-Ole |
| 分类号 | A61K38/36;A61K38/00;A61P7/08;A61P43/00;A61K38/14;A61K35/14;A61K38/16;C07K1/00;C07K14/00;C07K16/00;C07K17/00;C12P21/08;C07K14/47;A61K38/17;A61K45/06 | 主分类号 | A61K38/36 |
| 代理机构 | Womble Carlyle Sandridge & Rice LLP | 代理人 | Womble Carlyle Sandridge & Rice LLP |
| 主权项 | 1. A chimeric molecule of a ficolin-associated polypeptide comprising: a) a human ficolin-associated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a variant thereof having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO: 1; and b) an inhibitor of complement activation;wherein said chimeric molecule inhibits complement activation. | ||
| 地址 | Copenhagen O DK | ||