发明名称 |
Epsilon toxin epitopes from <i>Clostridium perfringens </i>with reduced toxicity |
摘要 |
There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin. |
申请公布号 |
US9573981(B2) |
申请公布日期 |
2017.02.21 |
申请号 |
US201314387809 |
申请日期 |
2013.03.28 |
申请人 |
University of Exeter |
发明人 |
Titball Richard W.;Bokori-Brown Monika;Naylor Claire |
分类号 |
A61K39/08;C07K14/33;C07K16/12;A61K39/00 |
主分类号 |
A61K39/08 |
代理机构 |
Dorsey & Whitney, LLP |
代理人 |
Dorsey & Whitney, LLP |
主权项 |
1. An epsilon toxin epitope polypeptide comprising a sequence at least about 260 amino acids in length with at least 95% identity to SEQ ID NO:3 and having a mutation at position Y43, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. |
地址 |
Exeter GB |