发明名称 Epsilon toxin epitopes from <i>Clostridium perfringens </i>with reduced toxicity
摘要 There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin.
申请公布号 US9573981(B2) 申请公布日期 2017.02.21
申请号 US201314387809 申请日期 2013.03.28
申请人 University of Exeter 发明人 Titball Richard W.;Bokori-Brown Monika;Naylor Claire
分类号 A61K39/08;C07K14/33;C07K16/12;A61K39/00 主分类号 A61K39/08
代理机构 Dorsey & Whitney, LLP 代理人 Dorsey & Whitney, LLP
主权项 1. An epsilon toxin epitope polypeptide comprising a sequence at least about 260 amino acids in length with at least 95% identity to SEQ ID NO:3 and having a mutation at position Y43, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5.
地址 Exeter GB