发明名称 |
moduladores de transporte nuclear e usos dos mesmos |
摘要 |
The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity. |
申请公布号 |
BR112014001933(A2) |
申请公布日期 |
2017.02.21 |
申请号 |
BR20141101933 |
申请日期 |
2012.07.26 |
申请人 |
KARYOPHARM THERAPEUTICS, INC |
发明人 |
DILARA MCCAULEY;JEAN-RICHARD MARTIN;MICHAEL KAUFFMAN;SHARON SHACHAM;SHARON SHECHTER;VINCENT P. SANDANAYAKA;WILLIAM SENAPEDIS;YOSEF LANDESMAN |
分类号 |
C07D213/50;A61K31/407;A61K31/4196;A61K31/421;A61K31/4439;A61K31/454;A61K31/497;A61K31/506;C07D401/08;C07D401/12;C07D401/14;C07D403/08;C07D403/12;C07D413/12;C07D487/10 |
主分类号 |
C07D213/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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