Topical pharmaceutical composition comprising nanonized silver sulfadiazine

摘要

The invention relates to a topical pharmaceutical composition for burn treatment and microbial infections on human beings or animals. The pharmaceutical composition comprises 0.1% w/w to 1.0% w/w of an antimicrobial drug, i.e., silver sulfadiazine and 0.2% w/w antiseptic, i.e., chlorhexidine gluconate, wherein silver sulfadiazine is in nanonized form.

主权项

1. A dose-reduced topical pharmaceutical composition consisting of 0.5% w/w of nanonized silver sulfadiazine and 0.2% w/w chlorhexidine gluconate, and one or more pharmaceutically acceptable excipients selected from the group consisting of thickening agents, emulsifying agents, preservatives, chelating agents, pH modifiers, coloring agents, perfumes, and antioxidants, wherein the topical pharmaceutical composition exhibits a similar efficacy when compared to a marketed composition containing 1.0% w/w micronized silver sulfadiazine.