Demineralized bone fibers having controlled geometry and shapes and methods thereof

摘要

A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.

主权项

1. A bone repair composition, comprising:
a plurality of elongated bone fibers cut from cortical bone demineralized to a calcium content of no more than 10%; the plurality of elongated bone fibers cut along the direction of collagen fibers in the demineralized bone; the plurality of elongated bone fibers having a length from about 1 cm to about 30 cm, a width from about 0.05 mm to about 4 mm, and a thickness from about 0.05 mm to about 4 mm; and the plurality of elongated bone fibers having a plurality of cross sections with at least 60% uniformity within one standard deviation.