Protocols for treatment of major depressive disorder (MDD)

摘要

Although it is known that certain benzylpiperazine-aminopyridines or open chain forms thereof are effective in stimulating neural growth in in vitro tests, it has now been surprisingly found that administering these compounds in a dosage range of 10 mg/day-130 mg/day over 25-35 days is effective in treating Major Depressive Disorder (MDD) such that statistically significant results can be obtained with samples of only six subjects.

主权项

1. A method to treat major depressive disorder (MDD) in a human subject, which method comprises administering to a subject diagnosed with MDD an amount of a compound of formula (1) or formula (2) in the amount of 10 milligrams-130 milligrams per day (mg/day), wherein said subject is evaluated at the end of administration and after at least one month thereafter.