Naphthalene derivative

摘要

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I);
(R is as defined in the description)

or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

主权项

1. A compound of formula (I)wherein
R is 3-pyridyl, wherein
3-pyridyl is optionally substituted by 1 to 3 substituent selected from the group consisting of halo, alkyl, alkenyl which is optionally substituted by phenyl, alkoxy which is optionally substituted by pyridyl, tetrahydrofuranyl, halo or alkoxy, phenyl, naphthalenyl, pyridyl, thiophenyl, oxazolyl, dibenzofuranyl, benzothiophenyl, dibenzothiophenyl which is optionally substituted by pyridylmethoxy, chloropyridinecarbonylaminopropoxy or hydroxypropoxy, dioxodibenzothiophenyl, thianthrenyl, and quinolinyl which is optionally substituted by methyl;
wherein phenyl substituting 3-pyridyl is optionally substituted by 1 to 3 substituent selected from the group consisting of halo, alkyl which is optionally substituted by morpholinyl or up to 3 halo, alkoxy which is optionally substituted by hydroxy, carboxyl, butoxycarbonylamino, chloropyridinecarbonylamino or dioxodihydroisoindolyl, phenyl which is optionally substituted by halo or alkyl, alkylthio, acetyl, phenoxy, methoxycarbonylethylcarbonyl, cyano, phenylcarbonyl, hydroxy and formyl,or a pharmaceutically acceptable salt or solvate thereof.