Salts of carnitine derivatives and methods of production

摘要

Disclosed are salts, such as nitrates, of acetyl-L-carnitine and propionyl-L-carnitine and methods of making the compounds.

主权项

1. A method of producing acetyl-L-carnitine nitrate comprising:
reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base; isolating the acetyl-L-carnitine free base; reacting the acetyl-L-carnitine free base with nitric acid to produce acetyl-L-carnitine nitrate; and isolating the acetyl-L-carnitine nitrate, wherein reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base comprises dissolving the L-carnitine in acetic acid, and wherein the reaction between L-carnitine and acetic anhydride occurs at a temperature of between 30° C. and 80° C.