Use of androgens for vascular regeneration and endothelial repair

摘要

The present invention relates to the field of therapy and prophylaxis of vascular tissue damage and/or complications and/or disease of vascular tissue by vascular regeneration and endothelium repair. The inventors have found that administration of an androgen receptor agonist alleviates one or more adverse vascular diseases and/or vascular complications thereof or adverse effects of androgen deficiency, with implications for prophylactic and therapeutic interventions.

主权项

1. A method of promoting or enhancing vascular repair in a male subject who is suffering from a vascular blockage, wherein the method comprises administering to the subject a composition comprising a therapeutically effective amount of an androgen receptor agonist so that the subject is chronically exposed to the androgen receptor agonist, and wherein the composition is administered in an amount sufficient to stimulate angiogenesis, neovascularization and/or vascular regeneration in the subject to thereby promote or enhance vascular repair in the subject, wherein the vascular blockage is a result of critical limb ischaemia or thromboangiitis obliterans.