Pyrazolopyridine derivatives for use in the treatment of bladder cancer

摘要

The invention relates to the use of compounds corresponding to formula (I), or a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.;

主权项

1. A method for treating a bladder cancer comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein:
R1 is an aryl or heteroaryl group optionally substituted with one or more substituents independently selected from the group consisting of:
a halogen atom,a cyano group,an —NR5R5′ group, where R5 and R5′ are independently a hydrogen atom or a linear alkyl group,an —NR7R8 group, where R7 and R8 form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms independently selected from the group consisting of a nitrogen atom and an oxygen atom,a —COR10 group, where R10 is a hydroxyl group or an —NR5R5′ group, where R5 and R5′ are independently a hydrogen atom or a linear alkyl group,a —CONR6R6′ group, where R6 and R6′ form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms independently selected from the group consisting of a nitrogen atom and an oxygen atom,an —NHSO2CH3 group, andan —OR9 group, where R9 is a linear (C1-C3)alkyl group; or R1 is a bicyclic group of formula A: wherein R12 and R12′ form, together with the carbon atoms to which they are attached, a heterocycloalkyl comprising one or more heteroatoms independently selected from the group consisting of a nitrogen atom and an oxygen atom;
R2 is a haloalkyl group;R3 is:
an aryl group, optionally substituted with one or more alkoxy groups, ora heteroaryl group; andR4 is:
a hydrogen atom, ora linear (C1-C3)alkyl group, optionally substituted with an —NR5R5′ group, where R5 and R5′ are independently a hydrogen atom or a linear alkyl group, or an —NR6R6′ group, where R6 and R6′ form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms independently selected from the group consisting of a nitrogen atom and an oxygen atom; provided that the compound of formula (I) is other than 3-(3-methoxyphenyl)-6-(4-methoxyphenyl)-1-methyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridine.