Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma

摘要

The present invention relates to diagnostic, prognostic and clinical methods of distinguishing high-risk IPMN from more benign IPMN as well as high-grade PanIN and PDAC from low-grade PanIN with moderate sensitivity and very high specificity using Das-1 and related antibodies.

主权项

1. A method for determining whether a subject has high-risk intraductal papillary mucinous neoplasm (IPMN) of the pancreas comprising:
contacting a pancreatic fluid sample selected from the group consisting of a pancreatic cyst fluid and pancreatic juice from a subject suspected of having high-risk IPMN with a Das-1 antibody or an antigen binding portion thereof, wherein said Das-1 antibody is produced by a hybridoma deposited under American Type Culture Collection (ATCC) accession number HB 9397; and detecting the presence or absence of immunoreactivity between the pancreatic fluid sample and the antibody or the antigen binding portion thereof, the presence of the immunoreactivity indicating a positive diagnosis of having high-risk IPMN.