发明名称 |
Anticuerpo anti-CD4 |
摘要 |
An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell. The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof. |
申请公布号 |
ES2602459(T3) |
申请公布日期 |
2017.02.21 |
申请号 |
ES20090835062T |
申请日期 |
2009.12.25 |
申请人 |
Kyowa Hakko Kirin Co., Ltd. |
发明人 |
NAKAGAWA, Tomoaki;HORI, Sayaka;NIWA, Rinpei;KUBOTA, Tsuguo;MASUDA, Kazuhiro;NAKAMURA, Kazuyasu |
分类号 |
C12N15/09;A61K39/395;A61P35/00;A61P37/04;C07K14/73;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08;C12Q1/02;G01N33/53;G01N33/531 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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