Skin permeation device for analyte sensing or transdermal drug delivery

摘要

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

主权项

1. A controlled abrasion device comprising a hand piece, an abrasive tip, a feedback control mechanism, and an electrical motor, wherein the feedback control mechanism comprises (a) a source electrode that applies an electrical signal to an area of skin, (b) a return electrode and (c) a controller, and
wherein the feedback control mechanism measures in real time dynamic change of an electrical parameter at a skin site and calculates a rate of change in the electrical parameter over time when the device is applied to the skin to control the level of skin abrasion, wherein the electrical signal does not cause permanent damage to the skin, and wherein, after the rate of change in the electrical parameter reaches a maximum value, the controller stops the abrasion when the rate of change in the electrical parameter decreases to a set percentage of the maximum value or a preset value that is less than the maximum value.