Method of inducing a T lymphocyte response using T-cell immunogens derived from anti-viral proteins

摘要

Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.

主权项

1. A method of inducing a T lymphocyte response in an individual to a host cell infected with a human immunodeficiency virus (HIV), the method comprising administering to the individual an immunogenic composition comprising a polypeptide consisting of from 9 amino acids to about 150 amino acids, wherein said polypeptide comprises the amino acid sequence of one of SEQ ID NOs:11-14, and 16.