| 发明名称 | Chimeric fibronectin matrix mimetics and uses thereof | ||
| 摘要 | The present invention is directed to recombinant fibronectin peptide mimetics and wound healing compositions the same. Other aspects of the present invention include wound healing dressings that comprise the healing composition of the present invention and a wound dressings material and methods of treating wounds using these compositions. | ||
| 申请公布号 | US9572869(B2) | 申请公布日期 | 2017.02.21 |
| 申请号 | US201514743485 | 申请日期 | 2015.06.18 |
| 申请人 | University of Rochester | 发明人 | Hocking Denise;Roy Daniel C. |
| 分类号 | A61K38/00;A61K38/39;C07K14/78;A61K38/17;A61K38/18;C07K14/47;A61K45/06;A61K47/42 | 主分类号 | A61K38/00 |
| 代理机构 | LeClairRyan, a Professional Corporation | 代理人 | LeClairRyan, a Professional Corporation |
| 主权项 | 1. A wound healing composition comprising: a recombinant fibronectin peptide mimetic comprising: (i) at least a portion of the type III heparin-binding domain FNIII1H of fibronectin, wherein said portion comprises a heparin binding sequence and(ii) at least a portion of the type III integrin-binding domain FNIII8-10 of fibronectin, wherein said portion comprises an integrin binding sequence and does not contain FNIII9 in its entirety, wherein the at least a portion of the type III integrin binding domain comprises an amino acid sequence corresponding to amino acids 1266-1356 of SEQ ID NO:1 linked to amino acids 1447-1536 of SEQ ID NO: 1; and a synthetic material. | ||
| 地址 | Rochester NY US | ||