| 发明名称 | Cell permeable inhibitors of anaphase promoting complex | ||
| 摘要 | The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism. | ||
| 申请公布号 | US9572788(B2) | 申请公布日期 | 2017.02.21 |
| 申请号 | US201414276994 | 申请日期 | 2014.05.13 |
| 申请人 | President and Fellows of Harvard College | 发明人 | King Randall;Zeng Xing;Sackton Katharine L. |
| 分类号 | A61K31/27;A61K31/506;A61P35/00;A61N5/10;A61K45/06;A61K31/436;A61K31/138;A61K31/337;A61K31/4196;A61K31/496;A61K31/555;A61K47/48 | 主分类号 | A61K31/27 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Beattie Ingrid A. |
| 主权项 | 1. A synergistic composition comprising a prodrug of tosyl-L-arginine methylester (TAME) and apcin or an analog or derivative thereof, wherein the prodrug of TAME is proTAME: and wherein the apcin comprises wherein said composition diffuses across the plasma membrane of a cell. | ||
| 地址 | Cambridge MA US | ||