发明名称 |
ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) BIOMARKER PROTEINS (AHUS) |
摘要 |
The disclosure provides biomarker proteins, a change in the concentration or activity level of which are associated with atypical hemolytic uremic syndrome (aHUS) or clinically meaningful treatment of aHUS with a complement inhibitor. Also provided are compositions and methods for interrogating the concentration and/or activity of one or more of the biomarker proteins in a biological fluid. The compositions and methods are useful for, among other things, evaluating risk for developing aHUS, diagnosing aHUS, determining whether a subject is experiencing the first acute presentation of aHUS, monitoring progression or abatement of aHUS, and/or monitoring response to treatment with a complement inhibitor or optimizing such treatment. |
申请公布号 |
HK1218443(A1) |
申请公布日期 |
2017.02.17 |
申请号 |
HK20160106445 |
申请日期 |
2016.06.06 |
申请人 |
ALEXION PHARMACEUTICALS INC. |
发明人 |
MCKNIGHT, Susan Faas;COFIELL, Roxanne;KUKREJA, Anjli;BEDARD, Krystin, A.;YAN, Yan |
分类号 |
G01N |
主分类号 |
G01N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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