发明名称 |
Degradation of Beta-Amyloid Proteins With Keratinase |
摘要 |
The present invention involves using a keratinase enzyme to degrade beta-amyloid proteins and plaques related to Alzheimer's disease. |
申请公布号 |
US2017042980(A1) |
申请公布日期 |
2017.02.16 |
申请号 |
US201615339093 |
申请日期 |
2016.10.31 |
申请人 |
Johnson Kirk Steven |
发明人 |
Johnson Kirk Steven |
分类号 |
A61K38/48;A61K9/12;C07K16/28;A61K9/00 |
主分类号 |
A61K38/48 |
代理机构 |
|
代理人 |
|
主权项 |
1. By treating patients diagnosed with Alzheimer's disease with the keratinase enzyme the plaques caused by the beta-amyloid fibers will degrade and this will slow progression of disease and help prevent patient from negative consequences of the dementia. Creating a bio-medical product with the enzyme and attaching it to something that can cross the blood brain barrier can accomplish this. Examples of this are:
Coupling or creating a chimeric protein with the enzyme attached to a single chain variable fragment with a low affinity binding to the Transferrin receptor Administering the enzyme in a nasal mucosa or aerosol for passive entry into the brain along the olfactory nerve. |
地址 |
Ewa Beach HI US |