CULTURE MEDIUM COMPOSITION FOR INDUCING MUSCULOSKELETAL PROGENITOR CELL, AND PHARMACEUTICAL COMPOSITION COMPRISING MUSCULOSKELETAL PROGENITOR CELL FOR PREVENTING OR TREATING MUSCULOSKELETAL DISEASES

摘要

The present invention relates to: a culture medium composition for inducing differentiation of a musculoskeletal progenitor cell from a stem cell; a method for inducing differentiation of a musculoskeletal progenitor cell from a stem cell using the culture medium composition; a musculoskeletal progenitor cell produced by the method; and a pharmaceutical composition and a cell therapeutic agent containing the cell for preventing or treating musculoskeletal diseases. The culture medium composition according to the present invention contains an LIF, and is capable efficiently inducing differentiation of a musculoskeletal progenitor cell from a stem cell by activating FGF2 signal transfer, inhibiting TGF-β/activin/nodal signal transfer, activating a Wnt signal, and inhibiting an ERK signal. The musculoskeletal progenitor cell obtained thereby can be differentiated into a bone through endochondral ossification, and also into cartilage, tendon, and muscle, and therefore can be useful in preventing or treating a variety of musculoskeletal diseases.